Autoimmunity and malignancy
نویسنده
چکیده
Recent papers published had suggested the association of malignancy with autoimmune disease. Numerous autoimmune phenomena have been reported in cancer patients. There is a bidirectional relationship between autoimmunity and malignancy. Patients with autoimmune conditions develop neoplastic diseases and, analogously, various autoantibodies have been detected in the sera of patients with hematological and epithelial malignancies. A wide variety of cancer types have been associated with the autoimmune disorders, which raises a question about immune reactions to the tumor as a cause of the autoimmune disorder. It was suggested that the generation of autoantibodies in malignant conditions is an aspect of immune deficiency or an immune response against proteins which are involved in proliferative functions. The intent of this paper is not to provide a comprehensive review of autoimmunity and malignancy but rather to illustrate the relationship between autoimmunity and malignancy.
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